We have continually curated important research papers and other resources, under topic headings, on COVID-19 to provide a quick and easy guide to current evidence.
DASHBOARDS
UNSW Time Series Modelling global dashboard
ESRI ARC GIS Australia COVID-19 DASHBOARD
Johns Hopkins KAP COVID (social and behavioural data)
Carnegie Mellon COVIDCast (US data)
"Policy Tracker" Launched by the IMF March 25, summarizes the key economic responses governments are taking to limit the human and economic impact of the COVID-19 pandemic as of March 24, 2020.
The Oxford COVID-19 Government Response Tracker was launched on March 24 and counts data from 73 countries so far, including China, South Korea, Italy, UK and USA. T
Paediatric cases and vertical transmission
Infection in contacts of children aged year K-12
American academy of pediatrics data on child COVID-19 cases
Household secondary attack rate highest when index case is a child
SARS-CoV-2 in cardiac tissue of a child
Role of children in household transmission
Study showing higher viral shedding in children <5 years
School cluster of COVID-19 in France
Good summary of schools, children and COVID-19
Multisystem inflammatory disease in children
Lower ACE2 receptor expression in children<10 years compared to people >10 years
2005 study showing association of coronaviruses with Kawasaki disease
SARS CoV 2 viral loads in children vs adults
Persistent viral shedding in children (Nature Medicine)
Epidemiology in children (review)
Lu et al. SARS-COV2 in Children. NEJM 2020
Detection of COVID in febrile children in January in Wuhan
Yuanyuan Dong, Xi Mo, Yabin Hu,et al. Epidemiological Characteristics of 2143 Pediatric Patients
With 2019 Coronavirus Disease in China. Pediatrics. 2020; doi: 10.1542/peds.2020-0702
Cai, J. X. J., Daojiong, L; et al (2020). "A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features." Clinical Infectious Diseases.
Chan, J. F.-W., et al. (2020). "A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster." The Lancet.
Wei, M., et al. (2020). "Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China." JAMA.
Chen, H. G., J; Wang, C; et al (2020). "Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records." Lancet.
Asymptomatic children can shed virus for 10 days or more. Lancet.
Lay summary of risk of transmission in kids
Transmission dynamics
Increased transmissibility of B117 variant in the UK
Transmissibility of B117 variant
Household attack rates in the US
Epidemiology and transmission dynamics in 2 Indian states (large contact tracing study)
Secondary household attack rates - metaanalysis
Data from 3 outbreak clusters with presymptomatic transmission
85% attack rate on a fishing trawler
Household contact study from the US
Airborne transmission as the dominant mode
Projecting the transmission dynamics of SARS CoV 2 through the post-pandemic period
High transmission near symptom onset
Li, Q., et al. (2020). "Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia." New England Journal of Medicine.
Chan, J. F.-W., et al. (2020). "A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster." The Lancet.
Liu, Y. E., R.M; Kucharski, A.J (2020). "Secondary attack rate and superspreading events for SARS-CoV-2." Lancet.
Stephen A. Lauer, MS, PhD *; Kyra H. Grantz, BA *; Qifang Bi, MHS; Forrest K. Jones, MPH; Qulu Zheng, MHS; Hannah R. Meredith, PhD; Andrew S. Azman, PhD; Nicholas G. Reich, PhD; Justin Lessler, PhD. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application https://annals.org/aim/fullarticle/2762808/incubation-period-coronavirus-disease-2019-covid-19-from-publicly-reported
Retracted study (reasons unknown) showed transmission of COVID19 over 4.5m on a bus https://www.scmp.com/news/china/science/article/3074351/coronavirus-can-travel-twice-far-official-safe-distance-and-stay
COVID can survive in the air for 3 hours https://www.medrxiv.org/content/10.1101/2020.03.09.20033217v1.full.pdf
Prof Don Milton on WHO statement that COVID-19 is not airborne
Transmission at a bath centre in China
Droplets generated through normal speech
Coronaviruses exhaled in normal breathing, prevented by a mask
Viral shedding, immunology, immunity (including duration of shedding and shedding in “recovered” patients or reinfection), pathology and PCR-testing studies
Summary of variant strains and vaccine escape potential
SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma
Antibody dependent enhancement
Antibody responses to SARS CoV 2 infection (IgA, IgM)
Anti-phospholipid antibodies and thormbosis
Will SARS CoV 2 become endemic (Science)
Ultra-potent human antibodies to SARS CoV 2
Loss of SARS CoV 2 antibodies in mild infection
Antibody-like proteins that capture and neutralize SARS-CoV-2
Antibody Profiles and Mild or Severe SARS-CoV-2
Differential Tropism of SARS-CoVs in Bat Cells
SARS-CoV-2 in Quarantined Domestic Cats from COVID-19 Households or Close Contacts, Hong Kong, China
Short term immunity from seasonal coronaviruses
Viral shedding in severe and mild cases
Long duration of viral shedding
Reinfection with more severe infection the second time
A case of reinfection in Hong Kong
How long should isolation be - review of viral shedding data
Pre-existing immunity to SARS-CoV-2: the knowns and unknowns
ACE2 expression in resp tract of adults, children, patients with COPD
Cases who re-test positive after discharge - data from S Korea suggest not infectious
Infection gradient in the respiratory tract (Cell)
Reinfection with seasonal coronaviruses
Proportion of test positive cases in Seattle and Washington State EDs and outpatient clinics
Virological assessment of hospitalized patients with COVID-2019 (Nature)
Zou, L., et al. (2020). "SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients." New England Journal of Medicine. (contains data on asymptomatic shedding)
Lan, L. X. D. Y. G. e. a. (2020). "Positive RT-PCR Test Results in Patients Recovered From COVID-19." JAMA.
Zhang, J. W., S; Xue, Y (2020). "Fecal Specimen Diagnosis 2019 Novel Coronavirus-Infected Pneumonia." J Med Virol.
Study in macaques on reinfection
Low levels of antibodies in recovered patients
Viral shedding in upper and lower respiratory tract
Asymptomatic infection and transmission
Viral load in asymptomatic higher than symptomatic
Transmission risk in outdoor and indoor settings
Mass screening in Wuhan and asymptomatic infection
OUtbreak data on proportion symptomatic and asymptomatic
Long distance spread of SARS CoV 2 in a hospital
Aerosol transmission between ferrets
Clinical and immunological features of asymptomatic infection
Modelling of Diamond Princess outbreak shows 69% of transmission was from asymptomatic
Half of infections on cruise ship were asymptomatic
Prevalence of asymptomatic infection - review (Annals Int Med)
Asymptomatic and presymptomatic transmission in an outbreak in Germany (Lancet)
Asymptomatic infection on the Diamond Princess
Natural history of asymptomatic infection (NEJM)
Summary of different studies showing high rates of asymptomatic infection
Up to 44% infections occur when index case is presymptomatic (Nature)
Asymptomatic infection in aged care (CDC)
Asymptomatic infection in aged care (NEJM)
Asymptomatic infection - population screening in Iceland
Relative transmissibility of asymptomatic cases
Nishiura, H., et al. (2020). "The Rate of Underascertainment of Novel Coronavirus (2019-nCoV) Infection: Estimation Using Japanese Passengers Data on Evacuation Flights." Journal of Clinical Medicine 9(2): 419.
Hoehl S, Rabenau H, Berger A, Kortenbusch M, Cinatl J, Bojkova D, et al. Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China. New England Journal of Medicine. 2020.
Bai, Y. Y., Lingsheng;Wei, Tao; Tian, Fei; Jin, Dong-Yan; Chen,Lijuan; Wang, Meiyun (2020). "Presumed Asymptomatic Carrier Transmission of COVID-19." JAMA Published online February 21, 2020. doi:10.1001/jama.2020.2565.
Rothe, C. S., M; Sothmann, P; et al (2020). "Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany." New England Journal of Medicine.
Lin, C. D., Y; Xie, B; et al (2020). "Asymptomatic Novel Coronavirus Pneumonia Patient Outside Wuhan: The Value of CT Images in the Course of the Disease." Clinical Imaging 63: 7-9.
Lu, C. L., X; Jia, Z (2020). "2019-nCoV transmission through the ocular surface must not be ignored." Lancet 395(10224): E39.
Kenji Mizumoto, Katsushi Kagaya, Alexander Zarebski, Gerardo Chowell. medRxiv 2020.02.20.20025866; doi: https://doi.org/10.1101/2020.02.20.20025866
Zou, L., et al. (2020). "SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients." New England Journal of Medicine. (contains data on asymptomatic shedding)
Jing Cai1, Wenjie Sun1, Jianping Huang1, Michelle Gamber, Jing Wu , and Guiqing He. Indirect Virus Transmission in Cluster of COVID-19 Cases, Wenzhou, China, 2020 EID 2020; 26: early release.
Roman Woelfel, Corman, MV; Guggemos, W et Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission clusteral https://www.medrxiv.org/content/10.1101/2020.03.05.20030502v1
Riyun Li, Sen Pei, Bin Chen et al. Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2). Science 16 Mar 2020:
Why testing matters - the case study of USA
Summary of evidence on infectious period
Use of masks for sick patients - human coronaviruses
Barrier box for endotracheal intubation (NEJM)
Transmission from deceased patients in a morgue
Substantial undocumented transmission of SARS CoV 2
Airborne transmission of SARSCoV 2
Comparative aerosol efficiency of SARS, SARS COV2 and MERS COV
Clinical characteristics and epidemiology (including case fatality rate)
Sequelae in Adults at 6 Months After COVID-19 Infection
Comparison of hospitalised influenza and COVID-19
Readmission in death in survivors
Varying severity of disease in identical twins
Lower risk of COVID in people with asthma
Evidence of SARS CoV 2 in the US in December 2019
Risk factors for COVID-19 - meta-analysis. Hypertension, CVD, COPD, diabetes
Incidence and treatment of arrhythmias secondary to coronavirus infection in humans
Chronic manifestations of COVID-19
Risk factors in US veterans - ethnicity not a risk factor
Risk factors for COVID-19 severe outcomes
Clinical presentations of COVID patients
Diffuse pulmonary arterial thrombosis in fatal cases
Large vessel stroke in younger adults, some without symptoms of COVID-19 (NEJM)
Kenji Mizumoto
and Gerardo Chowell. Estimating Risk for Death from 2019 Novel Coronavirus Disease, China, January–February 2020. EID. Volume 26, Number 6—June 2020
Zhou F, Du R et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. March 9, 2020 https://doi.org/10.1016/ S0140-6736(20)30566-3
Lauer SA, Grantz KH, Bi Q, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med. 2020; [Epub ahead of print 10 March 2020]. doi: https://doi.org/10.7326/M20-0504
Wang, D., et al. (2020). "Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China." JAMA.
Chen, N. Z., M; Dong X; et al (2020). "Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study." Lancet.
Guan, W. N., Z; Hu, Y; et al (2020). "Clinical Characteristics of Coronavirus Disease 2019 in China." New England Journal of Medicine.
Huang, C. W., Y; Li, X; et al (2020). "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China." Lancet.
Holshue, M. D., C; Lindquist, S; et al (2020). "First Case of 2019 Novel Coronavirus in the United States." New England Journal of Medicine.
Young, Ong, SWX; Kalimuddin, S; et al (2020). "Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore." JAMA.
The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team. The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) — China, 2020[J]. China CDC Weekly, 2020, 2(8): 113-122
Joseph T Wu, Kathy Leung, Mary Bushman, et al. Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China. Preprint, Nature Research. 2020 DOI: 10.21203/rs.3.rs-17453/v1
Case series from Seattle, NEJM
Coronavirus: Why it’s so deadly in Italy
Case fatality 7.2% in Italy - JAMA
CFR in Germany and European countries
Who has flattened the curve best?
Estimates of the severity of coronavirus disease 2019: a model-based analysis (Lancet)
Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19 (NEJM)
Olfactory epithelium and anosmia
Outbreaks in detention centres
Guillaine Barre Syndrome associated with SARS CoV 2 infection
Complex immune dysregulation (Cell)
Does MTB increase the risk of COVID19?
Antibody dependent immune enhancement with COVID19
R0 estimates, modelling and epidemic predictions
Manaus, Brazil - reinfection with P1
Infectiousness of B117 variant in the UK
Super-spreading and R0 estimates in Indonesia
Wu, J. L., K; Leung, G (2020). "Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study." Lancet 395(10225): 689-697.
Li, Q., et al. (2020). "Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia." New England Journal of Medicine.
Anderson, RM; Heesterbeek, H; Klinkenberg, D; Hollingsworth, TD. How will country-based mitigation measures influence the course of the COVID-19 epidemic? Lancet. Published:March 09, 2020DOI:https://doi.org/10.1016/S0140-6736(20)30567-5
De Salazar et al. Identifying Locations with Possible Undetected Imported Severe Acute Respiratory Syndrome Coronavirus 2 Cases by Using Importation Predictions. EID
Sensitivity of diagnostic tests including chest imaging
The fuss about cycle threshholds for PCR
Performance of self-collected nasal swabs
Wenling Wang, PhD1; Yanli Xu, MD2; Ruqin Gao, MD3; et alRoujian Lu, MPH1; Kai Han, BS2; Guizhen Wu, MD1; Wenjie Tan, MD, PhD1. Detection of SARS-CoV-2 in Different Types of Clinical Specimens JAMA. Published online March 11, 2020. doi:10.1001/jama.2020.3786
Xie, X., et al. (2020). "Chest CT for Typical 2019-nCoV Pneumonia: Relationship to Negative RT-PCR Testing." Radiology: 200343.
Lin, C. D., Y; Xie, B; et al (2020). "Asymptomatic Novel Coronavirus Pneumonia Patient Outside Wuhan: The Value of CT Images in the Course of the Disease." Clinical Imaging 63: 7-9.
Molecular diagnostics and antibody tests
Serological responses (IgM and IgG) to COVID 19
Neutralizing antibody response in recovered patients
Lower antibodies in asymptomatic infected
Immunological correlates of protection
Population serosurveys
Santa Clara County, California, USA
Elective surgery patients, Australia
Co-infection with other pathogens
Increased risk of death with influenza/SARS CoV 2 infection
Wang et al. Clinical diagnosis of 8274 samples with 2019-novel coronavirus in Wuhan. MerRIV 2020
Xiaojing Wu, Ying Cai, Xu Huang. Co-infection with SARS-CoV-2 and Influenza A Virus in Patient with Pneumonia, China. EID Volume 26, Number 6—June 2020
20% rate of co-infection (JAMA)
Phylogenetics and virology
Increased viral load with B117
NERVTAG report on increased severity and risk of death with UK variant
Explainer on variants of concern
Increased risk of death with B117
Evolution of mutations in immunocompromised host treated with convalescent plasma
Rapid genetic evolution in an immunocompromised host
The VUI-202012/01 (B117) mutation in the UK
Evolutionary origin of SARS CoV 2
Genetic epidemiology in Maryland
Interpretation of positive PCR after recovery
D614G mutation increases infectivity of SARS-CoV-2
Cryptic transmission in Washington state
The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity
Korber at al. The G vs D strain and explanation by Trevor Bedford
Roujian Lu, Xiang Zhao, Juan Li, Peihua Niu, Bo Yang, Honglong Wu, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet, Vol. 395, No. 10224, p565–574
Nextstrain.org from The Bedford Lab provides a continually updated phylogenetic tree
Phylogenetic analysis of SARS-CoV-2: https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College---COVID-19---genetic-analysis-FINAL.pdf
Xiaolu Tang, Changcheng Wu, Xiang Li, Yuhe Song, Xinmin Yao, Xinkai Wu, Yuange Duan, Hong Zhang, Yirong Wang, Zhaohui Qian. On the origin and continuing evolution of SARS-CoV-2. National Science Review, nwaa036, https://doi.org/10.1093/nsr/nwaa036 2020.
Kristian G. Andersen, Andrew Rambaut, W. Ian Lipkin, Edward C. Holmes & Robert F. Garry The proximal origin of SARS-CoV-2. Nature Medicine. 2020
The proximal origin of SARS CoV 2
Environmental contamination, aerosols, air sampling, hospital ward sampling, PPE and disinfection
Long-distance airborne dispersal of SARS-CoV-2 in COVID-19 wards
SARS CoV 2 in the air inside a car
Prof Don Milton lecture on aerosols
Is wiping surfaces of any use?
Assessment of Air Contamination by SARS-CoV-2 in Hospital Settings
Another building with transmission through air ducts
Aerosol generation during intubation, extubation and coughing
Virus on banknotes and touch screens for weeks
Effect of air purifiers in closed classrooms
Airborne transmission of SARS CoV2
Aerosol transmission in a choir practice
Viable airborne SARS CoV 2 in the absence of aerosol generating procedures
CDC list of disinfectants for SARS CoV 2
Aerosol generation and a novel hood for COVID-19 patients
Airborne transmission in aged care
Probable Evidence of Fecal Aerosol Transmission of SARS-CoV-2 in a High-Rise Building
Evidence of airborne transmission of SARS CoV2 including spread through a building
Aerodynamics of SARS CoV 2 in a hospital in Wuhan
Evidence of aerosol transmission
Airborne SARS-CoV-2 is Rapidly Inactivated by Simulated Sunlight
Reducing transmission of SARS CoV 2
Small droplet aerosols in poorly ventilated spaces and SARS-CoV-2 transmission
Study comparing original and modified WHO hand sanitizer formulation against SARS-CoV-2
Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals (Nature)
Aerosol transmission of SARSCoV2 - review
Sean Wei Xiang Ong, Yian Kim Tan, Po Ying Chia, et al. Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient JAMA. Published online March 4, 2020. doi:10.1001/jama.2020.3227
Van Dorelman et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. NEJM. March 17, 2020. DOI: 10.1056/NEJMc2004973
Kampf, G et al. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hosp Inf Cont. 2020. 104, Issue 3, Pages 246–251.
SARS-CoV 2 found on surfaces in the Diamond Princess 17 days after passengers disembarked
SARSCoV2 on banknotes, masks and other surfaces
SARS COV2 - environmental contamination, air vents, air samples and spread 4m from patient
Widespread contamination and airborne transmission - University of Nebraska Medical Center
Re-use and decontamination on N95 respirators
Persistence of aerosolised viable SARS-CoV2
Disinfection methods for re-using single use PPE
COVID-19 in air pollution particles
Antivirals, drugs and other treatments
Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults
RCT of Monoclonal antibody LYCoV555
Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia
Heparin - role of heparan sulfate in spike protein binding
Colchicine as a treatment (JAMA)
Hydroxychloroquine and azithromycin
Neutralising antibody in an animal model (Science)
Convalescent plasma (RCT) (JAMA)
No efficacy of HCQ as prophylaxis for contacts (NEJM)
No difference between 5 or 10 days of remdesevir
Remdesivir - shorter time to recovery (NEJM)
Hydroxychloroquine and chloroquine associated with increased mortality. - the veracity of the data in this study has been questioned and a letter signed by hundreds of scientists sent to Lancet
Expression of concern from Lancet about HCQ study above
Ivermectin shows invitro activity against SARS-CoV-2
COVID-19. hyperglycaemia and hydroxychloroquine
Lopinavir-ritonavir with and without IFNB
Anakinra (Lancet Rheumatology)
Elifky, A. (2020). "Anti-HCV, Nucleotide Inhibitors, Repurposing Against COVID-19." Life Science.
Sheahan, T. P. S., A.C; Leist, S.R; et al (2020). "Comparative Therapeutic Efficacy of Remdesivir and Combination Lopinavir, Ritonavir, and Interferon Beta Against MERS-CoV." Nature Communications 11(1): 222.
Gordon, C. J. T., E.P; Feng, J.Y; et. al (2020). "The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus." J Biological Chemistry.
Li, G. D. C., E (2020). "Therapeutic options for the 2019 novel coronavirus (2019-nCoV)." Nature Reviews 19.
Liying Dong 1, Shasha Hu 2, Jianjun Gao 1 Discovering Drugs to Treat Coronavirus Disease 2019 (COVID-19) Drug Discov Ther 14 (1), 58-60 2020
Is ibuprofen safe for people with COVID-19?
Cao B et al. A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
No evidence of improved viral clearance on hydroxychloroquine and azithromycin
Compassionate use of remdesivir (NEJM)
Should ACE inhibitors be continued?
ACEI/ARB not associated with mortality
ACEI not associated with in-hospital mortality (NEJM)
Vaccines
Neutralisation against variants of concern - Pfizer
Neutralisation against variants of concern - Moderna
Reduced efficacy of AZ vaccine in South Africa
Impact of vaccination in Israel
Reduced viral load after vaccination with Pfizer (Israel)
Sputnik vaccine interim phase 3
Commentary on Sputnik and other Ad vectored vaccines
Sinopharm vaccines neutralising ability against South African variant
Novavax press release - reduced efficacy against mutants
Novavax preclinical (animal) study
Moderna press release on UK, South African variants of concern
Adenoviral vectors for vaccines explained
Mandating COVID vaccines - legal and ethical considerations
Herd immunity through vaccination
Requirements for herd immunity with a vaccine
Sinovac CORONAVAC phase 1/2 RCT
The problems with adenovirus vectors explained
WHO summary of vaccines in development
Russian adenovirus 5 and 6 prime boost vaccine
Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine (Novavax/UQ)
List of authors.Attitudes to vaccines
Antibody dependent enhancement
Whole inactivated vaccine shows good immunogenicity and safety
https://www.nejm.org/doi/full/10.1056/NEJMoa2024671?query=featured_home
First in humans phase 1 trial of adenovirus 5 vectored COVID19 vaccine
No association between childhood BCG and COVID-19 (JAMA)
Eight different approaches to COVID19 vaccines explained
Overview of different vaccine approaches by Sinobiologicals
Behzadi MA and Leyva-Grado VH. Front Microbiol 2019 - Review. PMID 31275265 Free PMC article. Overview of Current Therapeutics and Novel Candidates Against Influenza, Respiratory Syncytial Virus, and Middle East Respiratory Syndrome Coronavirus Infections.
BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)
Treatment for severe acute respiratory distress syndrome from COVID-19
Vaccine development landscape for COVID-19
Influenza vaccine and viral interference with coronaviruses
Immunological and genomic correlates of protection and disease severity
Antibody responses and symptoms
Antibody dependent enhancement explained
Duration of immunity after infection
Cross reaction with human seasonal coronavirus memory T cells
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Inhibition of IFN by SARS CoV 2
Serological responses at 4 months after infection in Iceland
Immune responses in older people
SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
Cross-reactive S-reactive CD4 cells in SARS-CoV-2 negative people
Effectiveness of non-pharmaceutical measures (contact tracing, case isolation, quarantine, travel restrictions, PPE)
Evidence for masks against SARS CoV 2
Reducing transmission of SARS CoV 2
Assessing the impact of coordinated COVID-19 exit strategies across Europe
Universal masking in hospitals
Impact of lockdown in UK on health services
Valentina Costantino (1), David J Heslop (2), C Raina MacIntyre (1). The effectiveness of full and partial travel bans against COVID-19 spread in Australia for travellers from China. MedRxiv 2020.
Hellewell, J. A., S; Gimma, et al (2020). "Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts." Lancet Global Health.
Chinazzi M, Davis JT, Ajelli M, Gioannini C, Litvinova M, Merler S, Pastore Y Piontti A, Mu K, Rossi L, Sun K, Viboud C, Xiong X, Yu H, Halloran ME, Longini IM Jr, Vespignani A.The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak. Science. 2020 Mar 6. pii: eaba9757. doi: 10.1126/science.aba9757. [Epub ahead of print]
Peak, C. M., et al. (2017). "Comparing nonpharmaceutical interventions for containing emerging epidemics." Proceedings of the National Academy of Sciences 114(15): 4023-4028.
Nishiura, H. (2020). "Backcalculating the Incidence of Infection with COVID-19 on the Diamond Princess " Journal of Clinical Medicine 9(3): 657.
Rocklov, J. S., H; Wilder-Smith, A (2020). "COVID-19 Outbreak on the Diamond Princess Cruise Ship: Estimating the Epidemic Potential and Effectiveness of Public Health Countermeasures." J Travel Med.
Zhao, S. Z., Z; Cao, P; et al (2020). "Quantifying the association between domestic travel and the exportation of novel coronavirus (2019-nCoV) cases from Wuhan, China in 2020: a correlational analysis " Journal of Travel Medicine.
Anzai, A. K., T; Linto, NM; et al (2020). "Assessing the Impact of Reduced Travel on Exportation Dynamics of Novel Coronavirus Infection (COVID-19)." Journal of Clinical Medicine 9(2): 601.
Xinghuan Wang, Zhenyu Pan, Zhenshun Cheng. Association between 2019-nCoV transmission and N95 respirator use. medRxiv Feb 19 2020. doi: https://doi.org/10.1101/2020.02.18.20021881
Kenji Mizumoto, Gerardo Chowell. Transmission potential of the novel coronavirus (COVID-19) onboard the Diamond Princess Cruises Ship, 2020 MedRxiv 2020.02.24.20027649; doi: https://doi.org/10.1101/2020.02.24.20027649
Shi Zhao, Peihua Cao, Daozhou Gao, Zian Zhuang, Marc Chong, Yongli Cai, Jinjun Ran, Kai Wang, Yijun Lou, Weiming Wang, Lin Yang, Daihai He, Maggie H Wang. Modelling the coronavirus disease (COVID-19) outbreak on the Diamond Princess ship using the public surveillance data from January 20 to February 20, 2020
medRxiv 2020.02.26.20028449; doi: https://doi.org/10.1101/2020.02.26.20028449
Yixiang Ng, MSc1*; Zongbin Li, MBBS1*; Yi Xian Chua, et al. Evaluation of the Effectiveness of Surveillance and Containment Measures for the First 100 Patients with COVID-19 in Singapore — January 2–February 29, 2020. EID. Early Release / March 13, 2020 / 69
Ferguson, N et al. Impact of non-pharmaceutical interventions (NPIs) to reduce COVID19 mortality and healthcare demand
Difference between no, moderate or extensive social distancing in US (Columbia University model)
Non-pharmaceutical including universal face mask use measures for COVID-19 control in US
Aged care, prison, institutional, transport and occupational (non-health) and other risk-group outbreaks
Cruise ship outbreaks - Australia as a case study
A nightclub outbreak in Germany
Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 During Long Flight
Home outbreaks >50% of all outbreaks. Superspreading <2%
An outbreak on a bus suggestive of airborne transmission
Asymptomatic transmission on an aircraft linked to toilets
Long range transmission in a meat packing plant
OUtbreak on a navy ship (60% attack rate)
Systematic review of aged care outbreaks
Managed outbreak in Seattle assisted living facility
OUtbreak in aged care facility in Washington State
Church group outbreak in Arkansas
Serial testing in a veterans facility, US
Outbreak in a choir in Washington State
Outbreak in homeless shelters, US
COVID-19 in meat processing plants, US
Health workers
The effect of respiratory activity, ventilatory therapy and facemasks on total aerosol emissions
Seroprevalence in health workers in UK
Intubation does not generate as much aerosol as coughing
Origin of aerosol generating procedures
Study of HCW in the Netherlands
Low risk of infection of HCW in Taiwan
Study of HCW PPE and infection risk in China
Masks, N95, eye protection and physical distancing - WHO commissioned meta-analysis
Commentary on WHO meta-analysis
Risk of infection in HCW (Annals)
Deaths of health workers in China (NEJM)
Adams JG, Walls RM. Supporting the Health Care Workforce During the COVID-19 Global Epidemic. JAMA. Published online March 12, 2020. doi:10.1001/jama.2020.3972
Asymptomatic infection in health workers in the Netherlands
One in 5 HCW infected with COVID19 in UK
Cloth masks not suitable for health workers
Effectiveness of N95 respirators in protecting HCWs from COVID-19
Droplet or airborne precautions?
Risk of transmission in primary care
Masks, PPE, materials, efficacy and effectiveness and Design of DIY masks
Quantitative Protection Factors for Common Masks and Face Coverings
Effectiveness of eye protection
Face masks considerably reduce COVID-19 cases in Germany
Effectiveness of mask mandates
Evidence of effectiveness of community masks - Canada
Contamination and washing of cloth masks
Social and behavioral consequences of mask policies during the COVID-19 pandemic
Evidence for community mask use
Mandating masks works - data from Germany
A video case study of surgical vs cloth masks
Only those wearing a face-shield got infected
Gamma irradiation degrades N95 respirators
Clinical trials and other research on face masks from the MacIntyre research group
Our latest systematic review on masks for HCW, community and sick patients
Aerosol filtration of common fabrics
Use of nylon stockings over various masks
Principles for design of cloth masks
Testing of filtration of different DIY fabrics
Aerosol filtration of cotton and silk materials
Hospitals, Patients, and Health systems capacity
Seroprevalence in outpatients in Virgina
Nosocomial transmission of SARS-CoV-2
Remuzzi, A; Remuzzi, G. COVID-19 and Italy: what next? Lancet 2020. (includes modelling predictions) Published:March 13, 2020DOI:https://doi.org/10.1016/S0140-6736(20)30627-9
Novel contact tracing using digital technology
Oxford University government response tracker
LSTMH Hospital bed surge capacity tool
Screening of all pregnant women attending an antenatal service in NY find 13% infected
Resources for GPs
AusDoc COVID 19 Resources for Australian GPs
Please check the Prepublication papers on Medrxiv - some of the most important research has been shared on this site for rapid dissemination.