COVID-19 key research papers and resources

coronavirus and map of China

We have collected important research papers and other resources, under topic headings, on COVID-19 to provide a quick and easy guide to current evidence. Please feel free to let us know about other important new papers as they arise.  Scroll down to check the epidemic curves for global cases and countries of interest. These are updated regularly.

 

DASHBOARDS

UNSW Time Series Modelling global dashboard

ESRI ARC GIS Australia COVID-19 DASHBOARD

 

Paediatric cases and vertical transmission

 

Role of children in household transmission

Study showing higher viral shedding in children <5 years

School cluster of COVID-19 in France

SARS-CoV-2 infection in primary schools in northern France: A retrospective cohort study in an area of high transmission

Good summary of schools, children and COVID-19

 

Multisystem inflammatory disease in children

 

Renal disease in children

 

Outcomes in pregnant women

 

Kawasaki disease US

 

Kawasaki disease in the UK

 

Kawasaki diseases in France

 

Lower ACE2 receptor expression in children<10 years compared to people >10 years

 

2005 study showing association of coronaviruses with Kawasaki disease

 

SARS CoV 2 viral loads in children vs adults

 

NEJM COVID in children

 

Paediatric cases in the USA

 

Persistent viral shedding in children (Nature Medicine)

 

Epidemiology in children (review)

 

Lu et al. SARS-COV2 in Children. NEJM 2020

 

Detection of COVID in febrile children in January in Wuhan 

 

Yuanyuan Dong, Xi Mo, Yabin Hu,et al. Epidemiological Characteristics of 2143 Pediatric Patients
With 2019 Coronavirus Disease in China.  
Pediatrics. 2020; doi: 10.1542/peds.2020-0702 

Cai, J. X. J., Daojiong, L; et al (2020). "A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features." Clinical Infectious Diseases.

 

Chan, J. F.-W., et al. (2020). "A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster." The Lancet.

         

Wei, M., et al. (2020). "Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China." JAMA.

 

Chen, H. G., J; Wang, C; et al (2020). "Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records." Lancet.

 

Asymptomatic children can shed virus for 10 days or more. Lancet.

 

JAMA: neonatal COVID 19

 

SARSCoV2 in childen

 

Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study

 

Lay summary of risk of transmission in kids

 

Transmission dynamics

 

Airborne transmission as the dominant mode

 

Projecting the transmission dynamics of SARS CoV 2 through the post-pandemic period

 

High transmission near symptom onset

 

Li, Q., et al. (2020). "Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia." New England Journal of Medicine.

         

Chan, J. F.-W., et al. (2020). "A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster." The Lancet.

         

Liu, Y. E., R.M; Kucharski, A.J (2020). "Secondary attack rate and superspreading events for SARS-CoV-2." Lancet.

 

Stephen A. Lauer, MS, PhD *; Kyra H. Grantz, BA *; Qifang Bi, MHS; Forrest K. Jones, MPH; Qulu Zheng, MHS; Hannah R. Meredith, PhD; Andrew S. Azman, PhD; Nicholas G. Reich, PhD; Justin Lessler, PhD. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application https://annals.org/aim/fullarticle/2762808/incubation-period-coronavirus-disease-2019-covid-19-from-publicly-reported

 

Retracted study (reasons unknown) showed transmission of COVID19 over 4.5m on a bus  https://www.scmp.com/news/china/science/article/3074351/coronavirus-can-travel-twice-far-official-safe-distance-and-stay

COVID can survive in the air for 3 hours https://www.medrxiv.org/content/10.1101/2020.03.09.20033217v1.full.pdf

Tapiwa Ganyani, Cecile Kremer, Dongxuan Chen, Andrea Torneri, Christel Faes, Jacco Wallinga, Niel Hens. Estimating the generation interval for COVID-19 based on symptom onset data. MedRXiv 2020 doi: https://doi.org/10.1101/2020.03.05.20031815

 

Prof Don Milton on WHO statement that COVID-19 is not airborne

 

Transmission at a bath centre in China

 

Droplets generated through normal speech

 

Coronaviruses exhaled in normal breathing, prevented by a mask

 

Viral shedding, immunology, immunity (including duration of shedding and shedding in “recovered” patients or reinfection) and PCR-testing studies

 

Pre-existing immunity to SARS-CoV-2: the knowns and unknowns

 

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Cases who re-test positive after discharge - data from S Korea suggest not infectious

 

Infection gradient in the respiratory tract (Cell)

 

Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals

 

Viable virus in faeces 

 

Reinfection with seasonal coronaviruses 

 

Proportion of test positive cases in Seattle and Washington State EDs and outpatient clinics

 

Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study

Virological assessment of hospitalized patients with COVID-2019 (Nature)

 

Zou, L., et al. (2020). "SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients." New England Journal of Medicine.  (contains data on asymptomatic shedding)

 

Lan, L. X. D. Y. G. e. a. (2020). "Positive RT-PCR Test Results in Patients Recovered From COVID-19." JAMA.

         

Zhang, J. W., S; Xue, Y (2020). "Fecal Specimen Diagnosis 2019 Novel Coronavirus-Infected Pneumonia." J Med Virol.

 

Study in macaques on reinfection

 

Low levels of antibodies in recovered patients

 

Viral shedding in upper and lower respiratory tract

 

immune dysfunction in covid19

 

Reinfection

 

Asymptomatic infection and transmission

Clinical Course and Molecular Viral Shedding Among Asymptomatic and Symptomatic Patients With SARS-CoV-2 Infection in a Community Treatment Center in the Republic of Korea

Prevalence of asymptomatic infection - review (Annals Int Med)

Contact infection rate 

Asymptomatic and presymptomatic transmission in an outbreak in Germany (Lancet)

 

Asymptomatic infection on the Diamond Princess

 

Natural history of asymptomatic infection (NEJM)

 

Summary of different studies showing high rates of asymptomatic infection

 

Up to 44% infections occur when index case is presymptomatic (Nature)

 

Asymptomatic infection in aged care (CDC)

 

Asymptomatic infection in aged care (NEJM)

 

Asymptomatic infection - population screening in Iceland

 

Relative transmissibility of asymptomatic cases

 

Nishiura, H., et al. (2020). "The Rate of Underascertainment of Novel Coronavirus (2019-nCoV) Infection: Estimation Using Japanese Passengers Data on Evacuation Flights." Journal of Clinical Medicine 9(2): 419.

 

Hoehl S, Rabenau H, Berger A, Kortenbusch M, Cinatl J, Bojkova D, et al. Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China. New England Journal of Medicine. 2020.

 

Bai, Y. Y., Lingsheng;Wei, Tao; Tian, Fei; Jin, Dong-Yan; Chen,Lijuan; Wang, Meiyun (2020). "Presumed Asymptomatic Carrier Transmission of COVID-19." JAMA Published online February 21, 2020. doi:10.1001/jama.2020.2565.

         

Rothe, C. S., M; Sothmann, P; et al (2020). "Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany." New England Journal of Medicine.

 

Lin, C. D., Y; Xie, B; et al (2020). "Asymptomatic Novel Coronavirus Pneumonia Patient Outside Wuhan: The Value of CT Images in the Course of the Disease." Clinical Imaging 63: 7-9.

         

Lu, C. L., X; Jia, Z (2020). "2019-nCoV transmission through the ocular surface must not be ignored." Lancet 395(10224): E39.

         

Estimating the Asymptomatic Proportion of 2019 Novel Coronavirus onboard the Princess Cruises Ship, 2020

Kenji Mizumoto, Katsushi Kagaya, Alexander Zarebski, Gerardo Chowell. medRxiv 2020.02.20.20025866; doi: https://doi.org/10.1101/2020.02.20.20025866

 

Zou, L., et al. (2020). "SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients." New England Journal of Medicine.  (contains data on asymptomatic shedding)

Jing Cai1, Wenjie Sun1, Jianping Huang1, Michelle Gamber, Jing Wu , and Guiqing He. Indirect Virus Transmission in Cluster of COVID-19 Cases, Wenzhou, China, 2020 EID 2020; 26: early release.

 

Roman Woelfel, Corman, MV; Guggemos, W et Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission clusteral https://www.medrxiv.org/content/10.1101/2020.03.05.20030502v1

 

Riyun Li, Sen Pei, Bin Chen et al.  Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2)Science  16 Mar 2020:

 

Transmission in aircraft

 

Why testing matters - the case study of USA

 

Summary of evidence on infectious period

 

Use of masks for sick patients - human coronaviruses

 

SARS-CoV-2 in blood donations

 

Barrier box for endotracheal intubation (NEJM)

 

Transmission from deceased patients in a morgue

 

Substantial undocumented transmission of SARS CoV 2

 

Airborne transmission of SARSCoV 2

 

Comparative aerosol efficiency of SARS, SARS COV2 and MERS COV

 

Clinical characteristics and epidemiology (including case fatality rate)

 

Risk factors for COVID-19 severe outcomes

 

Clinical presentations of COVID patients

 

Post-mortem findings (JAMA)

 

Diffuse pulmonary arterial thrombosis in fatal cases

 

Large vessel stroke in younger adults, some without symptoms of COVID-19 (NEJM)

 

Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study

 

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

 

Kenji MizumotoImage removed.  and Gerardo Chowell. Estimating Risk for Death from 2019 Novel Coronavirus Disease, China, January–February 2020. EID. Volume 26, Number 6—June 2020

 

Zhou F, Du R et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. March 9, 2020 https://doi.org/10.1016/ S0140-6736(20)30566-3

 

Lauer SA, Grantz KH, Bi Q, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med. 2020; [Epub ahead of print 10 March 2020]. doi: https://doi.org/10.7326/M20-0504

 

Wang, D., et al. (2020). "Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China." JAMA.

         

Chen, N. Z., M; Dong X; et al (2020). "Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study." Lancet.

 

Guan, W. N., Z; Hu, Y; et al (2020). "Clinical Characteristics of Coronavirus Disease 2019 in China." New England Journal of Medicine.

         

Huang, C. W., Y; Li, X; et al (2020). "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China." Lancet.

         

Holshue, M. D., C; Lindquist, S; et al (2020). "First Case of 2019 Novel Coronavirus in the United States." New England Journal of Medicine.

         

Young, Ong, SWX; Kalimuddin, S; et al (2020). "Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore." JAMA.

         

The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team. The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) — China, 2020[J]China CDC Weekly, 2020, 2(8): 113-122

Joseph T Wu, Kathy Leung, Mary Bushman, et al. Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China. Preprint, Nature Research. 2020 DOI: 10.21203/rs.3.rs-17453/v1

 

Case series from Seattle, NEJM

 

Coronavirus: Why it’s so deadly in Italy

 

Case fatality 7.2% in Italy - JAMA

 

Patients dying in Italy

 

Cross country CFR comparision

 

CFR in Germany and European countries

 

Epidemiology in the US

 

Who has flattened the curve best?

 

Estimates of the severity of coronavirus disease 2019: a model-based analysis (Lancet)

 

Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19 (NEJM)

 

Olfactory epithelium and anosmia

 

Immune thrombocytopenia

 

Outbreaks in detention centres

 

Guillaine Barre Syndrome associated with SARS CoV 2 infection

 

Complex immune dysregulation (Cell)

 

Neurological complications

 

Does MTB increase the risk of COVID19?

 

Antibody dependent immune enhancement with COVID19

 

 

R0 estimates, modelling and epidemic predictions

Wu, J. L., K; Leung, G (2020). "Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study." Lancet 395(10225): 689-697.

         

Li, Q., et al. (2020). "Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia." New England Journal of Medicine.

 

Anderson, RM; Heesterbeek, H; Klinkenberg, D; Hollingsworth, TD. How will country-based mitigation measures influence the course of the COVID-19 epidemic? Lancet. Published:March 09, 2020DOI:https://doi.org/10.1016/S0140-6736(20)30567-5

 

De Salazar et al. Identifying Locations with Possible Undetected Imported Severe Acute Respiratory Syndrome Coronavirus 2 Cases by Using Importation Predictions. EID

 

 

Sensitivity of diagnostic tests including chest imaging

Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction–Based SARS-CoV-2 Tests by Time Since Exposure

 

Performance of self-collected nasal swabs

 

Wenling Wang, PhD1; Yanli Xu, MD2; Ruqin Gao, MD3; et alRoujian Lu, MPH1; Kai Han, BS2; Guizhen Wu, MD1; Wenjie Tan, MD, PhD1. Detection of SARS-CoV-2 in Different Types of Clinical Specimens JAMA. Published online March 11, 2020. doi:10.1001/jama.2020.3786

 

Xie, X., et al. (2020). "Chest CT for Typical 2019-nCoV Pneumonia: Relationship to Negative RT-PCR Testing." Radiology: 200343.

 

Lin, C. D., Y; Xie, B; et al (2020). "Asymptomatic Novel Coronavirus Pneumonia Patient Outside Wuhan: The Value of CT Images in the Course of the Disease." Clinical Imaging 63: 7-9.

 

Molecular diagnostics and antibody tests

 

Serological responses (IgM and IgG) to COVID 19

 

Neutralizing antibody response in recovered patients

 

Antibody responses

 

Lower antibodies in asymptomatic infected

 

Use of salivary testing

 

Immunological correlates of protection

Severe Acute Respiratory Syndrome Coronavirus 2−Specific Antibody Responses in Coronavirus Disease 2019 Patients

 

Population serosurveys 

Vo, Italy 

Santa Clara County, California, USA

Iceland

Los Angeles, USA

Bergamo, Italy

Geneva, Switzerland

Spain

 

Co-infection with other pathogens

Wang et al. Clinical diagnosis of 8274 samples with 2019-novel coronavirus in Wuhan. MerRIV 2020

Xiaojing Wu, Ying Cai, Xu Huang. Co-infection with SARS-CoV-2 and Influenza A Virus in Patient with Pneumonia, China. EID Volume 26, Number 6—June 2020

 

20% rate of co-infection (JAMA)

 

 

Phylogenetics and virology

 

Interpretation of positive PCR after recovery

 

D614G mutation increases infectivity of SARS-CoV-2

 

The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity

Korber at al. The G vs D strain  and explanation by Trevor Bedford

Roujian Lu, Xiang Zhao, Juan Li, Peihua Niu, Bo Yang, Honglong Wu, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet, Vol. 395, No. 10224, p565–574

Nextstrain.org from The Bedford Lab provides a continually updated phylogenetic tree  

Phylogenetic analysis of SARS-CoV-2: https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College---COVID-19---genetic-analysis-FINAL.pdf

Xiaolu Tang, Changcheng Wu, Xiang Li, Yuhe Song, Xinmin Yao, Xinkai Wu, Yuange Duan, Hong Zhang, Yirong Wang, Zhaohui Qian. On the origin and continuing evolution of SARS-CoV-2. National Science Review, nwaa036, https://doi.org/10.1093/nsr/nwaa036 2020.


Kristian G. Andersen, Andrew Rambaut, W. Ian Lipkin, Edward C. Holmes & Robert F. Garry The proximal origin of SARS-CoV-2. Nature Medicine. 2020

The proximal origin of SARS CoV 2

Synthetic SARS CoV 2

 

Environmental contamination, air sampling, hospital ward sampling, PPE and disinfection

Airborne SARS-CoV-2 is Rapidly Inactivated by Simulated Sunlight

Reducing transmission of SARS CoV 2

Small droplet aerosols in poorly ventilated spaces and SARS-CoV-2 transmission

Study comparing original and modified WHO hand sanitizer formulation against SARS-CoV-2

Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals (Nature)

Comparative dynamic aerosol efficiencies of three emergent coronaviruses and the unusual persistence of SARS-CoV-2 in aerosol suspensions (from NIH, USAMRID, UTMB, Tulane)

Aerosol transmission of SARSCoV2 - review

Sean Wei Xiang Ong, Yian Kim Tan, Po Ying Chia, et al. Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient JAMA. Published online March 4, 2020. doi:10.1001/jama.2020.3227

 

Van Dorelman et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. NEJM. March 17, 2020. DOI: 10.1056/NEJMc2004973

 

Kampf, G et al. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hosp Inf Cont. 2020. 104, Issue 3, Pages 246–251.

 

SARS-CoV 2 found on surfaces in the Diamond Princess 17 days after passengers disembarked

 

SARSCoV2 on banknotes, masks and other surfaces

 

SARSCoV2 in wastewater in US

 

SARS COV2 - environmental contamination, air vents, air samples and spread 4m from patient

 

Widespread contamination and airborne transmission - University of Nebraska Medical Center

 

Detection of Air and Surface Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Hospital Rooms of Infected Patients

 

Aerodynamic Characteristics and RNA Concentration of SARS-CoV-2 Aerosol in Wuhan Hospitals during COVID-19 Outbreak

 

Re-use and decontamination on N95 respirators

 

Persistence of aerosolised viable SARS-CoV2

 

Disinfection methods for re-using single use PPE

 

COVID-19 in air pollution particles

 

National academies of science (NAS) Rapid Expert Consultation on SARS-CoV-2 Survival in Relation to Temperature and Humidity and Potential for Seasonality for the COVID-19 Pandemic (April 7, 2020) (2020)

 

Other NAS rapid reviews

 

Antivirals, drugs and other treatments

Colchicine as a treatment (JAMA)

Low dose steroids

Hydroxychloroquine and azithromycin

 

Neutralising antibody in an animal model (Science)

 

Convalescent plasma (RCT) (JAMA)

 

Recombinant, soluble ACE2

 

No efficacy of HCQ as prophylaxis for contacts (NEJM)

 

No difference between 5 or 10 days of remdesevir

 

Remdesivir - shorter time to recovery (NEJM)

 

Hydroxychloroquine and chloroquine associated with increased mortality. - the veracity of the data in this study has been questioned and a letter signed by hundreds of scientists sent to Lancet

 

Expression of concern from Lancet about HCQ study above

 

Ivermectin shows invitro activity against SARS-CoV-2

 

COVID-19. hyperglycaemia and hydroxychloroquine

 

Lopinavir-ritonavir with and without IFNB

 

Anakinra (Lancet Rheumatology)

 

Remdesivir RCT (Lancet)

 

Elifky, A. (2020). "Anti-HCV, Nucleotide Inhibitors, Repurposing Against COVID-19." Life Science.

 

Sheahan, T. P. S., A.C; Leist, S.R; et al (2020). "Comparative Therapeutic Efficacy of Remdesivir and Combination Lopinavir, Ritonavir, and Interferon Beta Against MERS-CoV." Nature Communications 11(1): 222.

         

Gordon, C. J. T., E.P; Feng, J.Y; et. al (2020). "The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus." J Biological Chemistry.

         

Li, G. D. C., E (2020). "Therapeutic options for the 2019 novel coronavirus (2019-nCoV)." Nature Reviews 19.

 

Liying Dong 1Shasha Hu 2Jianjun Gao 1 Discovering Drugs to Treat Coronavirus Disease 2019 (COVID-19)  Drug Discov Ther 14 (1), 58-60  2020

 

Is ibuprofen safe for people with COVID-19?

 

Cao B et al. A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

 

remdesivir and chloroquine


No evidence of improved viral clearance on hydroxychloroquine and azithromycin

 

Compassionate use of remdesivir (NEJM)

 

RCT of hydroxychloroquine

 

Should ACE inhibitors be continued?

 

ACEI/ARB not associated with mortality

 

Convalescent serum

 

ACEI not associated with in-hospital mortality (NEJM)

 

Vaccines

 

https://www.nejm.org/doi/full/10.1056/NEJMoa2024671?query=featured_home

 

Moderna vaccine Phase 1 trial

First in humans phase 1 trial of adenovirus 5 vectored COVID19 vaccine

 

No association between childhood BCG and COVID-19 (JAMA)

 

Eight different approaches to COVID19 vaccines explained

 

Overview of different vaccine approaches by Sinobiologicals

  

Behzadi MA and Leyva-Grado VH. Front Microbiol 2019 - Review. PMID 31275265 Free PMC article. Overview of Current Therapeutics and Novel Candidates Against Influenza, Respiratory Syncytial Virus, and Middle East Respiratory Syndrome Coronavirus Infections.

 

BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)

 

Treatment for severe acute respiratory distress syndrome from COVID-19

 

Vaccine development landscape for COVID-19

 

Influenza vaccine and viral interference with coronaviruses

 

The Potential Role of Th17 Immune Responses in Coronavirus Immunopathology and Vaccine-induced Immune Enhancement

 

Immunological and genomic correlates of protection and disease severity

 

SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection

 

Deep immune profiling

 

Pre-existing immunity

 

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

 

Cross-reactive S-reactive CD4 cells in SARS-CoV-2 negative people

 

Effectiveness of non-pharmaceutical measures (contact tracing, case isolation, quarantine, travel restrictions, PPE)

 

Universal masking in hospitals

Physical distancing interventions and incidence of coronavirus disease 2019: natural experiment in 149 countries

Impact of lockdown in UK on health services

 

Comparison of Estimated Rates of Coronavirus Disease 2019 (COVID-19) in Border Counties in Iowa Without a Stay-at-Home Order and Border Counties in Illinois With a Stay-at-Home Order

 

Contact tracing efficacy

Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China

 

Valentina Costantino (1), David J Heslop (2), C Raina MacIntyre (1).  The effectiveness of full and partial travel bans against COVID-19 spread in Australia for travellers from China. MedRxiv 2020.

Hellewell, J. A., S; Gimma, et al (2020). "Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts." Lancet Global Health.

 

Chinazzi M, Davis JT, Ajelli M, Gioannini C, Litvinova M, Merler S, Pastore Y Piontti A, Mu K, Rossi L, Sun K, Viboud C, Xiong X, Yu H, Halloran ME, Longini IM Jr, Vespignani A.The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak. Science. 2020 Mar 6. pii: eaba9757. doi: 10.1126/science.aba9757. [Epub ahead of print]

 

Peak, C. M., et al. (2017). "Comparing nonpharmaceutical interventions for containing emerging epidemics." Proceedings of the National Academy of Sciences 114(15): 4023-4028.

         

Nishiura, H. (2020). "Backcalculating the Incidence of Infection with COVID-19 on the Diamond Princess " Journal of Clinical Medicine 9(3): 657.

         

Rocklov, J. S., H; Wilder-Smith, A (2020). "COVID-19 Outbreak on the Diamond Princess Cruise Ship: Estimating the Epidemic Potential and Effectiveness of Public Health Countermeasures." J Travel Med.

         

Zhao, S. Z., Z; Cao, P; et al (2020). "Quantifying the association between domestic travel and the exportation of novel coronavirus (2019-nCoV) cases from Wuhan, China in 2020: a correlational analysis " Journal of Travel Medicine.

 

Anzai, A. K., T; Linto, NM; et al (2020). "Assessing the Impact of Reduced Travel on Exportation Dynamics of Novel Coronavirus Infection (COVID-19)." Journal of Clinical Medicine 9(2): 601.

 

Xinghuan Wang, Zhenyu Pan, Zhenshun Cheng. Association between 2019-nCoV transmission and N95 respirator use. medRxiv Feb 19 2020. doi: https://doi.org/10.1101/2020.02.18.20021881 

 

Kenji Mizumoto, Gerardo Chowell. Transmission potential of the novel coronavirus (COVID-19) onboard the Diamond Princess Cruises Ship,   2020 MedRxiv 2020.02.24.20027649; doi: https://doi.org/10.1101/2020.02.24.20027649

 

Shi Zhao, Peihua Cao, Daozhou Gao, Zian Zhuang, Marc Chong, Yongli Cai, Jinjun Ran, Kai Wang, Yijun Lou, Weiming Wang, Lin Yang, Daihai He, Maggie H Wang. Modelling the coronavirus disease (COVID-19) outbreak on the Diamond Princess ship using the public surveillance data from January 20 to February 20, 2020

medRxiv 2020.02.26.20028449; doi: https://doi.org/10.1101/2020.02.26.20028449

 

Yixiang Ng, MSc1*; Zongbin Li, MBBS1*; Yi Xian Chua, et al. Evaluation of the Effectiveness of Surveillance and Containment Measures for the First 100 Patients with COVID-19 in Singapore — January 2–February 29, 2020. EID. Early Release / March 13, 2020 / 69

 

Ferguson, N et al. Impact of non-pharmaceutical interventions (NPIs) to reduce COVID19 mortality and healthcare demand

 

Difference between no, moderate or extensive social distancing in US (Columbia University model)

 

Non-pharmaceutical including universal face mask use measures for COVID-19 control in US

 

Aged care, prison, institutional and occupational (non-health) and other risk-group outbreaks

 

COVID-19 in US prisons

 

OUtbreak on a navy ship (60% attack rate)

 

Systematic review of aged care outbreaks

 

Managed outbreak in Seattle assisted living facility

 

OUtbreak in aged care facility in Washington State

 

Church group outbreak in Arkansas

 

Serial testing in a veterans facility, US

 

Outbreak in a choir in Washington State

 

COVID-19 in US prisons

 

Outbreak in homeless shelters, US

 

COVID-19 in meat processing plants, US

 

Health workers

Study of HCW in the Netherlands

Risk in HCW in UK

 

Study of HCW PPE and infection risk in China

 

Masks, N95, eye protection and physical distancing - WHO commissioned meta-analysis

 

Commentary on WHO meta-analysis

 

Risk of infection in HCW (Annals)

 

Deaths of health workers in China (NEJM)

 

Adams JG, Walls RM. Supporting the Health Care Workforce During the COVID-19 Global Epidemic. JAMA. Published online March 12, 2020. doi:10.1001/jama.2020.3972

Asymptomatic infection in health workers in the Netherlands

 

One in 5 HCW infected with COVID19 in UK

 

Cloth masks not suitable for health workers

 

Effectiveness of N95 respirators in protecting HCWs from COVID-19

 

Barrier intubation method

 

Droplet or airborne precautions?

 

Risk of transmission in primary care

 

PPE, materials, efficacy and effectiveness and Design of DIY masks

A video case study of surgical vs cloth masks

Only those wearing a face-shield got infected

The need of health policy perspective to protect Healthcare Workers during COVID-19 pandemic. A GRADE rapid review on the N95 respirators effectiveness

Coronavirus data from 4 RCTs

Gamma irradiation degrades N95 respirators

Clinical trials and other research on face masks from the MacIntyre research group

Our latest systematic review on masks for HCW, community and sick patients

N95 and COVID19 (from China)

Aerosol filtration of common fabrics

Use of nylon stockings over various masks

Principles for design of cloth masks

Testing of filtration of different DIY fabrics

A simple respiratory mask

Aerosol filtration of cotton and silk materials

Filtration of cloth masks

 

Hospitals, Patients, and Health systems capacity

 

Nosocomial transmission of SARS-CoV-2

 

Remuzzi, A; Remuzzi, G. COVID-19 and Italy: what next? Lancet 2020. (includes modelling predictions) Published:March 13, 2020DOI:https://doi.org/10.1016/S0140-6736(20)30627-9

 

Quarantine in Italy

 

ICU beds in Australia

 

Novel contact tracing using digital technology

 

Oxford University government response tracker

 

LSTMH Hospital bed surge capacity tool

 

Health systems India

 

Screening of all pregnant women attending an antenatal service in NY find 13% infected

 

Practical advice for older people and people with chronic illness

How to Protect Older People From the Coronavirus

 

Failures in response 

https://www.news.com.au/lifestyle/health/health-problems/stay-home-coronavirus-sufferers-incredible-display-of-selfishness/news-story/57b58910893c7f8101b23de16e9bb3cf

https://www.theaustralian.com.au/nation/coronavirus-man-with-covid19-visits-supermarket-after-quarantine-request/news-story/102048e70d8780baebc96a9bcfa673fd

 

 

Social issues, global political and other consequences

Fight over toilet paper

The Coronavirus Could Reshape Global Order

Geographic location of cases in Sydney

 

Resources for GPs

AusDoc COVID 19 Resources for Australian GPs

 

Please check the Prepublication papers on Medrxiv - some of the most important research has been shared on this site for rapid dissemination.

        

 

"Policy Tracker"  Launched by the IMF March 25, summarizes the key economic responses governments are taking to limit the human and economic impact of the COVID-19 pandemic as of March 24, 2020. 

The Oxford COVID-19 Government Response Tracker was launched on March 24 and counts data from 73 countries so far, including China, South Korea, Italy, UK and USA. T

 

 

 

 

Flattening the curve demonstrated -  Korea vs Italy, Iran, France, Germany, Spain